منابع مشابه
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of ...
متن کاملSusceptibility of Primary Sensory Cortex to Spreading Depolarizations.
UNLABELLED Spreading depolarizations (SDs) are recognized as actors in neurological disorders as diverse as migraine and traumatic brain injury (TBI). Migraine aura involves sensory percepts, suggesting that sensory cortices might be intrinsically susceptible to SDs. We used optical imaging, MRI, and field potential and potassium electrode recordings in mice and electrocorticographic recordings...
متن کاملAge-related impairment of metabovascular coupling during cortical spreading depolarizations.
30 Cortical spreading depolarizations (SDs) may lead to long-lasting alterations in 31 cerebral blood flow (CBF), which contribute to neuronal dysfunction and hypoxic tissue 32 injury. There is growing evidence to suggest that age-related structural and functional 33 alterations of the neurovascular unit significantly increase both the incidence of SDs and 34 aggravate their functional conseque...
متن کاملSubarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling
Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia. Physiologically, neurovascular coupling represents a focal increase in cerebral blood flow to meet increased metabolic demand of neurons within active regions of the brain. Neurovascular coupling is ...
متن کاملSpreading depolarizations cycle around and enlarge focal ischaemic brain lesions
How does infarction in victims of stroke and other types of acute brain injury expand to its definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread across the cerebral cortex, sometimes at remarkably regular intervals, occur in patients with all types of injury. Here, we show experimentally with in vivo real-time imaging that similar, spontaneous depolarizations ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Neurophysiology
سال: 2016
ISSN: 0736-0258
DOI: 10.1097/wnp.0000000000000275